The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.
B16黒色腫細胞でメラニン生合成の上でアンゼリカkeiskeiに含まれる代表的なカルコンの抑制効果。
Nat Prod Commun. 2012; 7; 1007-10;
Department of Forest Product Technology, Faculty of Forestry, Mulawarman University, Samarinda, 75123, Indonesia.
Abstract
In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.
加えて、ORACとDPPH分析のこれらのカルコンの酸化防止効果も、決定された。
興味深いことに、低い細胞毒性で、すべてのカルコン(1-5)は、B16黒色腫細胞でメラニン構造を阻害する。