Cardiovascular risk factors in a patient with diabetes mellitus and coronary artery disease: therapeutic approaches to improve outcomes: perspectives of a preventive cardiologist.
真性糖尿病と冠動脈疾患患者における心血管系危険因子:結果を改善する治療的なアプローチ:予防的心臓専門医の展望。
Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA. mdavidso@medicine.bsd.uchicago.edu
Abstract
In patients with diabetes mellitus (DM), a cardiovascular event is of critical concern because of the impact on long-term survival. Cardiovascular disease (CVD) is the leading cause of death for patients with DM, which makes the modification of risk factors in the patient with DM and CVD a primary focus of the preventive cardiologist. Management of this patient population should include pharmacologic interventions, such as antidyslipidemics (mainly statins) and oral anti-DM (or insulin) agents, as well as diet control, physical exercise, and smoking cessation. It is hoped that focus on the ABCs of treatment--hemoglobin A(1c), blood pressure, and cholesterol-lipid profile--along with ongoing and future studies on the effects of these interventions will help to reduce the significant morbidity and mortality from microvascular and macrovascular complications in these high-risk patients with DM.
心血管疾患(CVD)はDM患者の主要な死因である。
そして、それはDM患者における危険因子の変形とCVDを予防的心臓専門医の原発巣とする。
この患者集団の運営は、食事制御、運動と禁煙と同様に薬理学的介入(例えばantidyslipidemics(主にスタチン)と経口抗DM(またはインシュリン)薬剤)を含まなければならない。
これらの介入の効果の進行中および将来の研究と一緒の治療 ― ヘモグロビンA(1c)、血圧とコレステロール脂質プロフィール ― のABCへの焦点調節がこれらの高リスクDM患者で微小血管性および大血管合併症から有意な罹患率と死亡率を低下させるのを助けることが望まれる。