PubMed日本語 - NO2とPM10とすべての原因への長期の露出と女性の将来のコホートの原因別死亡率。―QLifePro医療翻訳医療翻訳 QLifePro



Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women.

Published date 2012 Dec 8

Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women.


Published date



Occup Environ Med. 2012;


Joachim Heinrich, Elisabeth Thiering, Peter Rzehak, Ursula Krämer, Matthias Hochadel, Knut M Rauchfuss, Ulrike Gehring, H-Erich Wichmann


Helmholtz Zentrum München-German Research Center for Environment and Health, Institute of Epidemiology I, , Neuherberg, Germany.


We assessed whether long-term exposure to air pollution is associated with all-cause and cause-specific mortality during a period of declining particulate matter concentrations.Approximately 4800 women aged 55 years from North Rhine-Westphalia, Germany, were followed for up to 18 years. Exposure to air pollution was assessed in two ways: (1) using the distance between the residential address and the nearest major road, as calculated from Geographic Information System data and (2) calculating 1-year average particulate matter concentrations below 10 µm (PM(10)) and nitrogen dioxide (NO(2)) levels using data from the nearest air-monitoring station data to the subjects' residences. Ninety-two per cent of all subjects lived in the same community during the entire follow-up period. Associations between mortality and exposure were assessed using Cox's proportional hazards models, including confounder adjustment.Sixteen per cent of women passed away during the follow-up period. An increase of 7 μg/m(3) PM(10) (IQR) was associated with an increased HR for all-cause (HR 1.15, 95% CI (1.04 to 1.27)), cardiopulmonary (HR 1.39, 95% CI (1.17 to 1.64)), and lung cancer mortality (HR 1.84, 95% CI (1.23 to 2.74)). An increase of 16 μg/m(3) (IQR) NO(2) exposure was associated with all-cause (HR 1.18, 95% CI (1.07 to 1.30)) and cardiopulmonary mortality (HR 1.55, 95% CI (1.30 to 1.84)). The association between cardiopulmonary mortality and PM(10) was reduced for the extended follow-up period, during which PM(10) concentrations (but not NO(2) concentrations) were lower. Living close to a major road was associated with an increased relative risk for all-cause, cardiopulmonary and respiratory mortality. These associations were temporally stable.Long-term exposure to ambient PM(10) and NO(2) was associated with increased mortality rates.


大気汚染への露出は、2つの方向で評価された: (1) 住居のアドレスと最も近い主要道路の間の距離を使用すること。
(そのことは、Geographic Information Systemデータと(2)被験者の居住地に最も近い空気モニタリング・ステーション・データからデータを使用している10のµm(PM(10))と二酸化窒素(NO(2))レベル以下で1年の平均粒子状物質濃度を算出しているから算出した)すべての被験者の92パーセントは、全ての追跡調査期間の間に同じ地域に住んでいた。
7μg/m(3)のPM(10)(IQR)の増加は、オール原因(HR 1.15、95%CI(1.04~1.27))(心肺(HR 1.39、95%CI(1.17~1.64)))と肺癌死亡率(HR 1.84、95%CI(1.23~2.74))のために増加したHRと関係していた。
16μg/m(3)(IQR)のNO(2)暴露の増加は、オール原因(HR 1.18、95%CI(1.07~1.30))と心肺死亡率(HR 1.55、95%CI(1.30~1.84))と関係していた。

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