PubMed日本語 - 高尿酸血とメタボリック症候群:イスラエルからの大きなコホートからのレッスン。―QLifePro医療翻訳医療翻訳 QLifePro



Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel.

Published date

Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel.


Published date


Isr Med Assoc J. 2012; 14; 676-80;


Eytan Cohen, Ilan Krause, Abigail Fraser, Elad Goldberg, Moshe Garty


Recanati Center for Medicine and Research, Petah Tikva, Israel.


BACKGROUND: There is a striking increase in the number of people with metabolic syndrome (MetS) as a result of the global epidemic of obesity and diabetes. Increasing evidence suggests that uric acid may play a role in MetS.


OBJECTIVES: To assess the prevalence of MetS in a large cohort from Israel and its association with hyperuricemia using the latest three definitions of MetS.


METHODS: We conducted a retrospective analysis of the database from a screening center in Israel, using the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), the International Diabetes Federation (IDF) and the Harmonizing definitions of MetS, to assess 12,036 subjects with an age range of 20-80 years.


RESULTS: The mean age of the study sample was 46.1 +/- 10.2 years and 69.8% were male. The prevalence of MetS was 10.6%, 18.2% and 20.2% in the revised NCEP ATP III, the IDF and the Harmonizing definitions respectively. The prevalence of hyperuricemia in subjects with MetS, for all three MetS definitions, was similar: 20.0%, 19.9% and 19.1% respectively. There was a graded increase in the prevalence of MetS among subjects with increasing levels of uric acid. The increasing trend persisted after stratifying for age and gender and after multivariate analysis (P for trend (0.001).


CONCLUSIONS: This large cohort shows a high prevalence of MetS in Israel, but is still lower than the prevalence in western countries. Hyperuricemia is common in those subjects and might be considered a potential clinical parameter in the definition of MetS.


方法20-80年の年齢の範囲で12,036人の被験者を評価するために、我々は修正された米国コレステロール教育プログラムAdult Treatment Panel III(NCEP ATP III)、国際糖尿病連合(IDF)とMetSのHarmonizing定義を用いてイスラエルのスクリーニング・センターから、データベースの後向き分析を行った。
結果研究検体の平均年齢は46.1 +/- 10.2歳であった、そして、69.8%は男性だった。
MetSの有病率は、それぞれ修正されたNCEP ATP III、IDFとHarmonizing定義の10.6%、18.2%と20.2%であった。
増加している傾向は、年齢と性のために、そして、多変量解析の後層になった後に持続した(傾向のP (0.001)。

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