PubMed日本語 - アロエベラの利点とラット過敏性腸症候群のマトリカリアrecutitaを混ぜたもの:抗酸化剤と鎮痙性効果の組合せ。―QLifePro医療翻訳医療翻訳 QLifePro


Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects.


Published date



Chin J Integr Med. 2012;


Azar Asadi-Shahmirzadi, Shilan Mozaffari, Yara Sanei, Maryam Baeeri, Reza Hajiaghaee, Hamid Reza Monsef-Esfahani, Mohammad Abdollahi


Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 1417614411, Iran.


OBJECTIVE: To evaluate the beneficial effects of a mixture of Aloe vera (AV) and Matricaria recutita (German chamomile, GC) in an experimental model of irritable bowel syndrome (IBS). METHODS: IBS was induced by a 5-day restraint stress in rats including the groups of control (water), GC (300 mg/kg), loperamide (10 mg/kg), mixed AV and GC (50: 50 at doses of 150, 300 or 450 mg/kg assigned as Mix-150, Mix-300 and Mix-450, respectively) and the sham group which did not receive any restraint stress and was fed with saline. All medications were administered intragastrically by gavage for 7 days, 2 days as pre-treatment followed by 5 days during induction of IBS every day before restraining. RESULTS: The increased tumor necrosis factor alpha (TNF-α), myeloperoxidase (MPO) activity, and lipid peroxidation (LPO) in colonic cells in the control group were significantly decreased in the treatment groups. GC inhibited only small bowel transit while the AV/GC mixture delayed gastric emptying at the doses of 150 and 300 mg/kg. The AV/GC mixture also reduced colonic transit and small bowel transit at the dose of 150 mg/kg. CONCLUSIONS: The severity of stress-induced IBS was diminished by the AV/GC mixture at all doses used but not dose-dependently, via inhibiting colonic MPO activity and improving oxidative stress status. The effect of the mixture was more effective than GC alone. The present results support effectiveness of the AV and GC combination in IBS.


目的 過敏性腸症候群(IBS)の実験モデルでアロエベラ(AV)とマトリカリアrecutita(ジャーマンカミルレ、GC)の混合物の薬効を評価すること。
方法 少しの拘束ストレスも受けなくて、食塩水で供給された制御(水)、GC(300mg/kg)、ロペラミド(10mg/kg)、混合AVとGC(それぞれ、混合物-150、混合物-300と混合物-450として割り当てられる150、300または450mg/kgの用量の50:50)と見せかけの群の群を含むラットで、IBSは5日の拘束ストレスによって誘発された。
結果 対照群の結腸細胞の増加したTNFアルファ(TNF-α)、ミエロペルオキシダーゼ(MPO)活性と脂質過酸化(LPO)は、治療群で有意に減少した。
結論: ストレス誘発性IBSの重症度は、使われるすべての用量のAV/GCを混ぜたものによって、しかし、用量依存的にでなく、結腸MPO活性を阻害して、酸化ストレス・ステータスを改善することを経て減弱した。

460万語の専門辞書を備えた医療者専用翻訳サービス QLifePro医療翻訳