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PubMed翻訳

Postpartum Remodeling, Lactation, and Breast Cancer Risk: Summary of a National Cancer Institute-Sponsored Workshop.

Published date 2012 Dec 21

Postpartum Remodeling, Lactation, and Breast Cancer Risk: Summary of a National Cancer Institute-Sponsored Workshop.

分娩後リモデリング、乳汁分泌と乳癌は、以下の危険を冒す:国立癌研究所が後援するワークショップの概要。

Published date

2012-12-21

Journal

J Natl Cancer Inst. 2012;

Author

Jessica M Faupel-Badger, Kathleen F Arcaro, Jane J Balkam, A Heather Eliassen, Foteini Hassiotou, Carlito B Lebrilla, Karin B Michels, Julie R Palmer, Pepper Schedin, Alison M Stuebe, Christine J Watson, Mark E Sherman

Affiliation

Affiliations of authors: Cancer Prevention Fellowship Program and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (JMF-B); Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA (KFA); School of Nursing, Notre Dame of Maryland University, Baltimore, MD (JJB); Channing Laboratory, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA (AHE); School of Chemistry and Biochemistry and School of Anatomy, Physiology and Human Biology, University of Western Australia, Crawley, Australia (FH); Department of Chemistry and Department of Biochemistry, University of California, Davis, CA (CBL); Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (KBM); Department of Epidemiology, Harvard School of Public Health, Boston, MA (KBM); Slone Epidemiology Center at Boston University, Boston, MA (JRP); Division of Medical Oncology, Anschutz Medical Center, University of Colorado-Denver, Denver, CO (PS); Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC (AMS); Department of Pathology, University of Cambridge, Cambridge, UK (CJW); Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, MD (MES).

Abstract

The pregnancy-lactation cycle (PLC) is a period in which the breast is transformed from a less-developed, nonfunctional organ into a mature, milk-producing gland that has evolved to meet the nutritional, developmental, and immune protection needs of the newborn. Cessation of lactation initiates a process whereby the breast reverts to a resting state until the next pregnancy. Changes during this period permanently alter the morphology and molecular characteristics of the breast (molecular histology) and produce important, yet poorly understood, effects on breast cancer risk. To provide a state-of-the-science summary of this topic, the National Cancer Institute invited a multidisciplinary group of experts to participate in a workshop in Rockville, Maryland, on March 2, 2012. Topics discussed included: 1) the epidemiology of the PLC in relation to breast cancer risk, 2) breast milk as a biospecimen for molecular epidemiological and translational research, and 3) use of animal models to gain mechanistic insights into the effects of the PLC on breast carcinogenesis. This report summarizes conclusions of the workshop, proposes avenues for future research on the PLC and its relationship with breast cancer risk, and identifies opportunities to translate this knowledge to improve breast cancer outcomes.

 

妊娠-乳汁分泌サイクル(社)は、胸部が発展途上、機能しない器官から新生児の栄養的な、発達上のおよび免疫予防必要を満たすために進化した、成熟した、乳産生腺に変えられる期間である。
乳汁分泌の停止は、胸部が次の妊娠まで静止状態に先祖返りするそれによってプロセスを開始する。
変化は、胸部(分子組織学)と重要な、これまでに十分によく理解されていない生産物の(乳癌リスクに対する効果)形態と分子特徴をこの期間中、永久に変える。
この主題の科学のありさま概要を提供するために、国立癌研究所は専門家の多くの専門にわたる群に2012年3月2日にロックビル(メリーランド)のワークショップに参加するよう促した。
検討される主題は、以下を含んだ: 1) 乳癌リスク(2)に関する社の疫学)分子疫学的および翻訳上の研究のためのバイオ標本として母乳、そして、3)胸部発癌性の上で社の効果に対する機械学の洞察を得る動物モデルの使用。
この報告はワークショップの終わりを要約して、PLCの将来の研究と乳癌リスクとのその関係のために通りを提案して、乳癌結果を改善するためにこの知識を翻訳する機会を同定する。


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