PubMed日本語 - 分娩後リモデリング、乳汁分泌と乳癌は、以下の危険を冒す:国立癌研究所が後援するワークショップの概要。―QLifePro医療翻訳医療翻訳 QLifePro



Postpartum Remodeling, Lactation, and Breast Cancer Risk: Summary of a National Cancer Institute-Sponsored Workshop.

Published date 2012 Dec 21

Postpartum Remodeling, Lactation, and Breast Cancer Risk: Summary of a National Cancer Institute-Sponsored Workshop.


Published date



J Natl Cancer Inst. 2012;


Jessica M Faupel-Badger, Kathleen F Arcaro, Jane J Balkam, A Heather Eliassen, Foteini Hassiotou, Carlito B Lebrilla, Karin B Michels, Julie R Palmer, Pepper Schedin, Alison M Stuebe, Christine J Watson, Mark E Sherman


Affiliations of authors: Cancer Prevention Fellowship Program and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (JMF-B); Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA (KFA); School of Nursing, Notre Dame of Maryland University, Baltimore, MD (JJB); Channing Laboratory, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA (AHE); School of Chemistry and Biochemistry and School of Anatomy, Physiology and Human Biology, University of Western Australia, Crawley, Australia (FH); Department of Chemistry and Department of Biochemistry, University of California, Davis, CA (CBL); Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (KBM); Department of Epidemiology, Harvard School of Public Health, Boston, MA (KBM); Slone Epidemiology Center at Boston University, Boston, MA (JRP); Division of Medical Oncology, Anschutz Medical Center, University of Colorado-Denver, Denver, CO (PS); Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC (AMS); Department of Pathology, University of Cambridge, Cambridge, UK (CJW); Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, MD (MES).


The pregnancy-lactation cycle (PLC) is a period in which the breast is transformed from a less-developed, nonfunctional organ into a mature, milk-producing gland that has evolved to meet the nutritional, developmental, and immune protection needs of the newborn. Cessation of lactation initiates a process whereby the breast reverts to a resting state until the next pregnancy. Changes during this period permanently alter the morphology and molecular characteristics of the breast (molecular histology) and produce important, yet poorly understood, effects on breast cancer risk. To provide a state-of-the-science summary of this topic, the National Cancer Institute invited a multidisciplinary group of experts to participate in a workshop in Rockville, Maryland, on March 2, 2012. Topics discussed included: 1) the epidemiology of the PLC in relation to breast cancer risk, 2) breast milk as a biospecimen for molecular epidemiological and translational research, and 3) use of animal models to gain mechanistic insights into the effects of the PLC on breast carcinogenesis. This report summarizes conclusions of the workshop, proposes avenues for future research on the PLC and its relationship with breast cancer risk, and identifies opportunities to translate this knowledge to improve breast cancer outcomes.


検討される主題は、以下を含んだ: 1) 乳癌リスク(2)に関する社の疫学)分子疫学的および翻訳上の研究のためのバイオ標本として母乳、そして、3)胸部発癌性の上で社の効果に対する機械学の洞察を得る動物モデルの使用。

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