PubMed日本語 - Candidatus Riesia pediculicolaで復号化している、セットされる最小のtRNAの修飾に近い?―QLifePro医療翻訳医療翻訳 QLifePro



Decoding in Candidatus Riesia pediculicola, close to a minimal tRNA modification set?

Published date

Decoding in Candidatus Riesia pediculicola, close to a minimal tRNA modification set?

Candidatus Riesia pediculicolaで復号化している、セットされる最小のtRNAの修飾に近い?

Published date


. 2012; 7; 11-34;


Valérie de Crécy-Lagard, Christian Marck, Henri Grosjean


Department of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Gainesville, FL 32611-0700, USA.


A comparative genomic analysis of the recently sequenced human body louse unicellular endosymbiont Candidatus Riesia pediculicola with a reduced genome (582 Kb), revealed that it is the only known organism that might have lost all post-transcriptional base and ribose modifications of the tRNA body, retaining only modifications of the anticodon-stem-loop essential for mRNA decoding. Such a minimal tRNA modification set was not observed in other insect symbionts or in parasitic unicellular bacteria, such as Mycoplasma genitalium (580 Kb), that have also evolved by considerably reducing their genomes. This could be an example of a minimal tRNA modification set required for life, a question that has been at the center of the field for many years, especially for understanding the emergence and evolution of the genetic code.


還元型ゲノム(582Kb)による最近配列決定されたヒト・コロモジラミ単細胞内部共生者Candidatus Riesia pediculicolaの比較のゲノム分析でそれがtRNA体のすべての転写後のベースとリボースの修飾を失ったかもしれない唯一の既知の生物であることが分かった。

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