PubMed日本語 - 交通関連の大気汚染暴露量とメキシコシティーの心拍変動性の変化:パネル調査。―QLifePro医療翻訳医療翻訳 QLifePro



Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: A panel study.

Published date 2013 Jan 18

Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: A panel study.


Published date



Environ Health. 2013; 12; 7;


Kyra Naumoff Shields, Jennifer M Cavallari, Megan J Hunt, Mariana Lazo, Mario Molina, Luisa Molina, Fernando Holguin



ABSTRACT: BACKGROUND: While air pollution exposures have been linked to cardiovascular outcomes, the contribution from acute gas and particle traffic-related pollutants remains unclear. Using a panel study design with repeated measures, we examined associations between personal exposures to traffic-related air pollutants in Mexico City and changes in heart rate variability (HRV) in a population of researchers aged 22 to 56 years. METHODS: Participants were monitored for approximately 9.5 hours for eight days while operating a mobile laboratory van designed to characterize traffic pollutants while driving in traffic and "chasing" diesel buses. We examined the association between HRV parameters (standard deviation of normal-to-normal intervals (SDNN), power in high frequency (HF) and low frequency (LF), and the LF/HF ratio) and the 5-minute maximum (or average in the case of PM2.5) and 30-, 60-, and 90-minute moving averages of air pollutants (PM2.5, O3, CO, CO2, NO2, NOx, and formaldehyde) using single- and two-pollutant linear mixed-effects models. RESULTS: Short-term exposure to traffic-related emissions was associated with statistically significant acute changes in HRV. Gaseous pollutants -- particularly ozone -- were associated with reductions in time and frequency domain components (alpha = 0.05), while significant positive associations were observed between PM2.5 and SDNN, HF, and LF. For ozone and formaldehyde, negative associations typically increased in magnitude and significance with increasing averaging periods. The associations for CO, CO2, NO2, and NOx were similar with statistically significant associations observed for SDNN, but not HF or LF. In contrast, PM2.5 increased these HRV parameters. CONCLUSIONS: Results revealed an association between traffic-related PM exposures and acute changes in HRV in a middle-aged population when PM exposures were relatively low (14 mug/m3) and demonstrate heterogeneity in the effects of different pollutants, with declines in HRV -- especially HF -- with ozone and formaldehyde exposures, and increases in HRV with PM2.5 exposure. Given that exposure to traffic-related emissions is associated with increased risk of cardiovascular morbidity and mortality, understanding the mechanisms by which traffic-related emissions can cause cardiovascular disease has significant public health relevance.


有意な正の関連がPM2.5とSDNN、HFとLFの間に観察される間、ガス状の汚染物質 ― 特にオゾン ― は時間と周波数領域成分(α= 0.05)の減少と関係していた。
結論:PM暴露量が比較的低くて(14マグ/m3)、PM2.5暴露で、オゾンとホルムアルデヒド暴露量によるHRV ― 特にHF ― の低下で、異なる汚染物質とHRVの増加の効果で異質性を示すとき、結果は中年の集団で交通関連のPM暴露量とHRVの深刻な変化の間の関係を明らかにした。

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