PubMed日本語 - 2本の転移-メチルニトロフェノールのペンダント腕によるシクロエヌ誘導剤:それらの銅(II)と亜鉛(II)複合体の構造研究。―QLifePro医療翻訳医療翻訳 QLifePro


Cyclen derivatives with two trans-methylnitrophenolic pendant arms: a structural study of their copper(II) and zinc(II) complexes.


Published date



Catarina V Esteves, Luís M P Lima, Pedro Mateus, Rita Delgado, Paula Brandão, Vítor Félix


Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.


Two new cyclen derivatives, H(2)do2nph and H(2)cb-do2nph, containing two trans-2-methyl-4-nitrophenol pendant arms and the latter including also an ethylene cross-bridge, were prepared in good yields using the bisaminal synthetic route. The two ligands were studied comparatively regarding their metal complexation behaviour. The copper(II) and zinc(II) complexes of H(2)do2nph and H(2)cb-do2nph were studied in dimethylsulfoxide-water (9 : 1 v/v) solution by a range of spectroscopic techniques. Copper(II) complexes were also studied in solid state by X-ray single crystal diffraction. These studies showed that the copper(II) and zinc(II) complexes of H(2)do2nph exhibited a distorted square pyramidal coordination environment with the four nitrogen atoms of the cyclen ring defining the basal plane, and that one of the nitrophenolate arms did not coordinate to the metal, independently of its protonation state. On the other hand, depending on the protonation state of one of the nitrophenolic arms, the cross-bridged derivative forms copper(II) complexes with distorted square pyramidal or octahedral geometries with one or two arms coordinated to the metal centre, respectively. In the complex with distorted octahedral geometry, the two phenolic oxygen atoms are coordinated to the metal centre in a cis-fashion. Acid-assisted dissociation assays in 1 mol dm(-3) HCl DMSO-H(2)O (9 : 1 v/v) solution at 298.2 K allowed one to determine the half-life of both copper(II) complexes, which is lower for the derivative without a cross-bridge as expected, while for the other one it is quite high and in line with similar cross-bridged cyclen derivatives from the literature.


他のもののためにそれが文献から全く高いおよび類似のクロス架橋されたシクロエヌ誘導剤と一致する間、298.2Kの1モルのdm(-3)HCl DMSOH(2)O(9:1のv/v)溶液の酸によって援助された解離分析法は1を両方の銅の(II)複合体(それは連結橋なしで誘導剤のために予想通りにより低い)の半減期を決定させた。

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