PubMed日本語 - 妊娠中の高血圧性障害と末期腎疾患の間の関係:人口に基づいた検査。―QLifePro医療翻訳医療翻訳 QLifePro



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Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study.


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I-Kuan Wang, Chih-Hsin Muo, Yi-Chih Chang, Chih-Chia Liang, Chiz-Tzung Chang, Shih-Yi Lin, Tzung-Hai Yen, Feng-Rong Chuang, Pei-Chun Chen, Chiu-Ching Huang, Chi-Pang Wen, Fung-Chang Sung, Donald E Morisky


Graduate Institute of Clinical Medical Science, the Department of Internal Medicine, China Medical University Hospital, and the Department of Public Health, China Medical University, Taichung, Taiwan.


BACKGROUND: Studies into the association between hypertensive disorders during pregnancy and end-stage renal disease are limited. We investigated the risk of end-stage renal disease after delivery among women with hypertensive disorders during pregnancy.


METHODS: We used insurance claims data from 1998 to 2009 to identify 26,651 women aged 19-40 years old who experienced hypertensive disorders during pregnancy; these women had no history of hypertension, diabetes, kidney disease or lupus. We also randomly selected 213,397 women without hypertensive disorders during pregnancy as a comparison cohort; the frequency was matched by age and index year of pregnancy. We compared the incidence of end-stage renal disease in the 2 cohorts. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) after controlling for demographic and clinical factors.


RESULTS: Women with hypertensive disorders during pregnancy had a greater risk of chronic kidney disease and end-stage renal disease, with adjusted HRs of 9.38 (95% CI 7.09-12.4) and 12.4 (95% CI 8.54-18.0), respectively, after controlling for urban status, coronary artery disease, congestive heart failure, hyperlipidemia and abruption. The HR for end-stage renal disease was 2.72 (95% CI 1.76-4.22) after we also controlled for hypertension and diabetes. Women with preeclampsia or eclampsia had a higher risk of end-stage renal disease (adjusted HR 14.0, 95% CI 9.43-20.7) than women who had gestational hypertension only (adjusted HR 9.03, 95% CI 5.20-15.7).


INTERPRETATION: Women with hypertensive disorders during pregnancy were at a high risk of end-stage renal disease. The risk was much greater for women who had preeclampsia or eclampsia than those who had gestational hypertension only.




結果妊娠中の高血圧性障害の女性は、都会に住む地位、冠動脈疾患、うっ血心不全、高脂血症と剥離のために制御した後に、慢性腎疾患のより大きなリスクと、それぞれ9.38(95%CI 7.09-12.4)と12.4(95%CI 8.54-18.0)の調整されたHRで、末期腎疾患を有した。
我々が高血圧と糖尿病のためにも制御したあと、末期腎疾患のためのHRは2.72(95%CI 1.76-4.22)であった。
子癇前症または子癇をもつ女性には、妊娠高血圧(調整されたHR 9.03、95%CI 5.20-15.7)だけを有した女性より高い末期腎疾患(調整されたHR 14.0、95%CI 9.43-20.7)のリスクがあった。


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